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Although targeting NMDA receptors for weight loss is not a new idea, previous attempts failed because of side effects such as hyperthermia and hyperlocomotion (excessive movement) that occur when NMDA receptors in the brain are inhibited indiscriminately 4

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J., Crocini, C

Among these approaches, the first-generation D+Q combination has accumulated the most experimental data regarding safety and efficacy, and CNS bioavailability (95-99)